NFAT1 (phospho Ser54) antibody-多抗-深圳欣博盛生物科技有限公司

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NFAT1 (phospho Ser54) antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX25246

规格：50μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NFAT1 (phospho Ser54) antibody

别名:

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 , AI607462 , NF-ATc2 , NF-ATp , NFAT1 , NFAT1-D , Nfatp

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

FCM, ICC/IF, WB

同种型:

IgG

免疫原:

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of mouse NFAT1 that contains serine 54.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

100

产品形式:

Liquid

存储溶液:

PBS, 0.1% BSA, 50% Glycerol, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT 1 (also known as NFATc2 or NFATp) is a 154 kDa member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT 1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT 1 has been shown to be important in the regulation of its transcriptional activity.

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