NFYA antibody-多抗-深圳欣博盛生物科技有限公司

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NFYA antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX26558

规格：100μg

目录价：￥9200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NFYA antibody

别名:

nuclear transcription factor Y subunit alpha , CBF-A , CBF-B , HAP2 , NF-YA

反应种属:

Human, Monkey

宿主来源:

Rabbit

实验应用:

ChIP assay, ELISA, EMSA, WB

同种型:

IgG

免疫原:

Synthetic NF-Y (A subunit) peptide corresponding to a region near the N-terminus of the human protein conjugated to KLH.

克隆性:

Polyclonal

克隆号:

纯化方式:

IgG fraction

偶联:

Unconjugated

产品浓度:

0.6 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

The Y box is a CCAAT box that is bound by the heteromeric DNA binding protein, NF-Y (also known as CBF and CP1). Unlike the transcription factors C/EBP and CTF/NF1, which also bind CCAAT-like sequences, NF-Y exhibits a strict binding requirement for this pentanucleotide sequence. Binding sites for this factor have been described for nearly 30% of all eukaryotic genes. Y/CCAAT sequences were frequently observed in the promoter-proximal sequences. NF-Y is composed of 3 separate subunits (A, B and C) each of which is required for DNA binding. Each subunit has remained highly conserved throughout evolution. In fact, homologous yeast subunits can substitute for mammalian NF-Y in DNA-binding assays. The conserved core sequences of NF-YB and NF-YC contain a 70 aa region similar to the histone fold motif of nucleosomes H2A and H2B. The unique structure and evolutionary conservation of this transcription factor suggests that it plays a fundamental role in the readout of eukaryotic genetic information.

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