nNOS antibody-多抗-深圳欣博盛生物科技有限公司

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nNOS antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX82905

规格：100μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

nNOS antibody

别名:

nitric oxide synthase 1, neuronal , 2310005C01Rik , N-NOS , NC-NOS , NO , NOS , NOS-I , Nos-1 , bNOS , nNOS

反应种属:

Bovine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish

宿主来源:

Rabbit

实验应用:

ICC/IF, IHC-Fr, IHC-P, IP, WB

靶标/特异性:

This antibody does not detect endothelial NOS (eNOS) or inducible NOS (iNOS).

同种型:

IgG

免疫原:

Synthetic peptide corresponding to residues T(724) K R R A I G F K K L A E A V K(739) C of rat bNOS.

克隆性:

Polyclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

160

产品形式:

Liquid

存储溶液:

Serum diluted with PBS, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. eNOS and bNOS share ~50% sequence homology, and their activity depends on binding to the calcium/calmodulin complex. Both constitutive isoforms respond immediately to increased levels of calcium to produce low levels of NO over a short period of time. bNOS has been found in neurons, peripheral nerve cells, macula densa & pancreatic islet cells.

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