NOTCH1 antibody-多抗-深圳欣博盛生物科技有限公司

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NOTCH1 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX28925

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NOTCH1 antibody

别名:

notch receptor 1 , AOS5 , AOVD1 , TAN1 , hN1

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

Dot, ELISA, ICC/IF, IHC-P, IP, Multiplexing, Neutralizing/Inhibition, WB

靶标/特异性:

This antibody reacts with mouse Notch constructs present in lysates of HEK 293 cells. Only the cleaved intracellular (activated) form (NICD) is detected. No reactivity is detected against mouse N2, N3 or N4. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form.

同种型:

IgG

免疫原:

Synthetic peptide corresponding to amino acid residues of human Notch 1 located near the N-terminal sequence of the cleaved N intracellular domain (NICD).

克隆性:

Polyclonal

克隆号:

偶联:

Unconjugated

产品浓度:

90 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

273

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

Notch 1 is synthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.

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