NPC1 antibody-多抗-深圳欣博盛生物科技有限公司

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NPC1 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX31790

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NPC1 antibody

别名:

NPC intracellular cholesterol transporter 1 , NPC , POGZ , SLC65A1

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

ELISA, IHC-P, WB

同种型:

IgG

免疫原:

NPC1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human NPC1.The immunogen is located within the last 50 amino acids of NPC1.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

142

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]

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