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折扣/货期| 货号：GTX00697 | 规格：100μg | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NUP98 antibody [2H10]
别名:
nucleoporin 98 , ADIR2 , NUP196 , NUP96
反应种属:
Human, Mouse, Rat, Saccharomyces cerevisiae, Schizosaccharomyces pombe
宿主来源:
Rat
实验应用:
ChIP assay, Dot, ELISA, ICC/IF, IP, WB
靶标/特异性:
We do not recommend use of this product for Tetrahymena.
同种型:
IgG2c
免疫原:
Recombinant GST-fused human Nup98 (amino acids 1-466)
克隆性:
Monoclonal
克隆号:
2H10
纯化方式:
Purified IgG
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Filter-sterilized PBS, 50% Glycerol, no preservatives.
生产商:
GeneTex
功能与背景:
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
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