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折扣/货期| 货号：AG-CR1-3674-M001 | 规格：1 mg | 目录价：￥600 |
| 货号：AG-CR1-3674-M005 | 规格：5 mg | 目录价：￥1740 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ONX 0914
别名:
N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide; PR-957
产品描述:
Potent and selective 20S immunoproteasome inhibitor. Targets the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=73nM) and with minimal cross-reactivity to the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=1.04µM). Potent anti-inflammatory and anticancer agent. Inhibits production of pro-inflammatory cytokines and can induce apoptosis in vitro. Inhibits presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, which consequently blocks production of interleukin-23 (IL-23) by activated monocytes and IFN-gamma and IL-2 by T cells. Can also inhibit IL-17-producing T cells under TH17-polarizing conditions in vitro and reduce TH1 and TH17 cell differentiation in vivo. Shown to attenuate disease progression in several experimental models of autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus, as well as in some hematologic malignancies and other cancer types.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
580.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
960374-59-8
分子式:
C31H40N4O7
溶解度:
Soluble in DMSO (30mg/ml), ethanol (20mg/ml) or DMF. Poorly soluble in aqueous solutions.
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