ONX 0914-抑制剂-深圳欣博盛生物科技有限公司

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ONX 0914

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3674-M001	规格：1 mg	目录价：￥720
货号：AG-CR1-3674-M005	规格：5 mg	目录价：￥1920

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ONX 0914

别名:

N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide; PR-957

产品描述:

Potent and selective 20S immunoproteasome inhibitor. Targets the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=73nM) and with minimal cross-reactivity to the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=1.04µM). Potent anti-inflammatory and anticancer agent. Inhibits production of pro-inflammatory cytokines and can induce apoptosis in vitro. Inhibits presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, which consequently blocks production of interleukin-23 (IL-23) by activated monocytes and IFN-gamma and IL-2 by T cells. Can also inhibit IL-17-producing T cells under TH17-polarizing conditions in vitro and reduce TH1 and TH17 cell differentiation in vivo. Shown to attenuate disease progression in several experimental models of autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus, as well as in some hematologic malignancies and other cancer types.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

580.7

产品形式:

solid

产地:

瑞士

纯度:

>98%