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折扣/货期| 货号：AG-CR1-3675-M001 | 规格：1 mg | 目录价：￥300 |
| 货号：AG-CR1-3675-M005 | 规格：5 mg | 目录价：￥780 |
| 货号：AG-CR1-3675-M025 | 规格：25 mg | 目录价：￥2640 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PI-1840 [Proteasome Inhibitor]
别名:
N-(1-Methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-acetamide
产品描述:
Highly potent, selective and rapidly reversible non-covalent proteasome inhibitor. Targets the chymotrypsin-like beta5-subunit of the constitutive 20S proteasome (IC50=27nM), with minimal cross-reactivity on the trypsin-like (beta2) and caspase-like/postglutamyl-peptide-hydrolysis-like (beta1) proteolytic activity (IC50= >100µM, for both). Exhibited over 100-fold selectivity for the constitutive 20S proteasome over the immunoproteasome. Anticancer compound. In vitro, induces the accumulation of proteasome substrates p27, Bax, and IkappaB-alpha, inhibits survival pathways and viability and induces apoptosis in intact cancer cells. Shown to inhibit tumor growth in mice of MDA-MB-231 breast tumors.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
394.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
1401223-22-0
分子式:
C22H26N4O3
溶解度:
Soluble in DMSO (30mg/ml) or ethanol (20mg/ml). Poorly soluble in aqueous solutions.
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