PI-1840 [Proteasome Inhibitor]-抑制剂-深圳欣博盛生物科技有限公司

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PI-1840 [Proteasome Inhibitor]

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3675-M001	规格：1 mg	目录价：￥300
货号：AG-CR1-3675-M005	规格：5 mg	目录价：￥780
货号：AG-CR1-3675-M025	规格：25 mg	目录价：￥2640

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PI-1840 [Proteasome Inhibitor]

别名:

N-(1-Methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-acetamide

产品描述:

Highly potent, selective and rapidly reversible non-covalent proteasome inhibitor. Targets the chymotrypsin-like beta5-subunit of the constitutive 20S proteasome (IC50=27nM), with minimal cross-reactivity on the trypsin-like (beta2) and caspase-like/postglutamyl-peptide-hydrolysis-like (beta1) proteolytic activity (IC50= >100µM, for both). Exhibited over 100-fold selectivity for the constitutive 20S proteasome over the immunoproteasome. Anticancer compound. In vitro, induces the accumulation of proteasome substrates p27, Bax, and IkappaB-alpha, inhibits survival pathways and viability and induces apoptosis in intact cancer cells. Shown to inhibit tumor growth in mice of MDA-MB-231 breast tumors.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

394.5

产品形式:

solid

产地:

瑞士

纯度:

>95% (HPLC)