Delanzomib [CEP-18770]-抑制剂-深圳欣博盛生物科技有限公司

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Delanzomib [CEP-18770]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3673-M001	规格：1 mg	目录价：￥360
货号：AG-CR1-3673-M005	规格：5 mg	目录价：￥1320
货号：AG-CR1-3673-M025	规格：25 mg	目录价：￥4560

产品详情

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产品名称:

Delanzomib [CEP-18770]

别名:

NPH 007098; CT 47098; CIP 18770; [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[(6-phenylpyridine-2-carbonyl)amino]butanoyl]amino]-3-methylbutyl]boronic acid

产品描述:

Potent, selective, reversible orally bioavailable proteasome inhibitor. Synthetic P2 threonine boronic acid. Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=3.8nM). Cross-reacts and inhibits the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=~70nM). Displays similar potency for the chymotrypsin-like activity of the proteasome compared to bortezomib. Exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors and bone marrow-derived stromal cells relative to bortezomib (Prod. No. AG-CR1-3602). Anticancer compound effective against multiple myeloma in vivo. In vitro, blocks the growth of representative human solid and hematological tumor cell lines (IC50s=5.6-34nM). Shown to down-modulate NF-kappaB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

413.3

产品形式:

solid

产地:

瑞士

纯度:

>95% (1H-NMR)