ORAI3 antibody-多抗-深圳欣博盛生物科技有限公司

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ORAI3 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX85442

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ORAI3 antibody

别名:

ORAI calcium release-activated calcium modulator 3 , TMEM142C

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, ICC/IF, IHC-P, WB

靶标/特异性:

This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

同种型:

IgG

免疫原:

ORAI3 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human ORAI3.The immunogen is located within the first 50 amino acids of ORAI3.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

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