UcH-L3 (human) (rec.) (untagged)-其他重组蛋白-深圳欣博盛生物科技有限公司

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UcH-L3 (human) (rec.) (untagged)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-DE0023-C050

规格：50 ug

目录价：￥3332

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

UcH-L3 (human) (rec.) (untagged)

别名:

Ubiquitin C-terminal Hydrolase L3; Ubiquitin Thioesterase L3

产品描述:

UCHL3 (Ubiquitin C-terminal Hydrolase L3) is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. It plays a role in regulating apical membrane recycling and indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response in retinal, skeletal muscle and germ cell maintenance. UCHL3 is also known to hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. It digests precursors and ubiquitinated proteins to generate monomeric ubiquitin.

宿主来源:

E. coli

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

~26kDa

产品形式:

liquid