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折扣/货期| 货号：GTX112864-S | 规格：25μl | 目录价：￥1700 |
| 货号：GTX112864 | 规格：100μl | 目录价：￥4000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PARP antibody [N2C1], Internal
别名:
poly(ADP-ribose) polymerase 1 , ADPRT , ADPRT 1 , ADPRT1 , ARTD1 , PARP , PARP-1 , PPOL , pADPRT-1
产品描述:
PARP antibody (more specifically, PARP1 antibody) detects poly(ADP-ribose) polymerase (PARP)-1, which is involved in various biological mechanisms such as DNA repair, genomic stability, and programmed cell death. Preclinical and clinical studies showed that PARP inhibition is an effective anti-tumor modality, and thus PARP inhibitors have become essential components of various chemotherapeutic regimens against many malignancies.
反应种属:
Human, Mouse
宿主来源:
Rabbit
实验应用:
ChIP assay, ICC/IF, IHC-P, IP, WB
靶标/特异性:
This antibody is specific for human PARP1 protein, and it does not cross react with human PARP2 and PARP3 protein.,IP/MS validation is based on published data (PMID: 30377409).
同种型:
IgG
免疫原:
Recombinant protein encompassing a sequence within the center region of human PARP1. The exact sequence is proprietary.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
113
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
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