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折扣/货期| 货号：GTX10845 | 规格：25μg | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PDGF-BB antibody
别名:
platelet derived growth factor subunit B , IBGC5 , PDGF-2 , PDGF2 , SIS , SSV , c-sis
反应种属:
Human
宿主来源:
Goat
实验应用:
ELISA, Neutralizing /Inhibition, WB
同种型:
IgG
免疫原:
Recombinant human PDGF-BB expressed in Escherichia coli.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
27
产品形式:
Liquid
存储溶液:
PBS, 5% Trehalose, no preservatives.
生产商:
GeneTex
功能与背景:
Platelet-Derived Growth Factor (PDGF) in serum is the principal mitogen present for cells of mesenchymal origin. PDGF is localized in alpha-granules of platelets and released during clot formation. PDGF from human platelets has been purified and described as a cationic glycoprotein (pI 9.5 to 10.4) having a molecular weight of approximately 30 kD and composed of two covalently linked subunits, designated as chains A (16 kD) and B (14 kD). In platelets, approximately 70% of the PDGF is present as the AB dimer, with most of the remainder as BB.Purified human PDGF shows substantial size heterogeneity, ranging from 27 to 31 kD, probably due to the presence of isoforms, glycosylation processing, aging of the platelets, and partial proteolysis during purification. The A and B chains are 40% homologous in sequence and are encoded by distinctly different genes. Each chain contains 8 cysteine residues, which are involved in intra- and inter-chain disulfide bonds. Cleavage of these bonds by reduction causes irreversible loss of biological activity. PDGF elicits multifunctional actions with a variety of cells.
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