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折扣/货期| 货号：GTX30716 | 规格：50μg | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PDI antibody [1D3]
别名:
Prolyl 4-Hydroxylase Subunit Beta , Pdi , Pdir , P4Hb
反应种属:
Bovine, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep, Xenopus laevis
宿主来源:
Mouse
实验应用:
ICC/IF, IHC, IP, WB
同种型:
IgG1
免疫原:
Peptide corresponding to amino acids 499-509 of rat protein disulfide isomerase conjugated to KLH.
克隆性:
Monoclonal
克隆号:
1D3
纯化方式:
Protein G affinity purified
偶联:
Unconjugated
产品浓度:
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
57
产品形式:
Liquid
存储溶液:
PBS, 50% Glycerol, 0.1mM PMSF, no preservatives.
生产商:
GeneTex
功能与背景:
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
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