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折扣/货期| 货号：GTX83886 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PIM2 antibody [10A12]
别名:
Pim-2 proto-oncogene, serine/threonine kinase
反应种属:
Dog, Human, Monkey, Rat
宿主来源:
Mouse
实验应用:
FCM, IHC-P, WB
同种型:
IgG2a
免疫原:
Full length human recombinant protein of human PIM2 (NP_006866) produced in HEK293T cell.
克隆性:
Monoclonal
克隆号:
10A12
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
0.84 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade | this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
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