PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-单抗-深圳欣博盛生物科技有限公司

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PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ7631

规格：100 ug

目录价：￥6488

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

产品描述:

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

反应种属:

Human, Rat, Monkey

宿主来源:

Mouse

实验应用:

WB, IF, FACS

同种型:

Mouse IgG2b

免疫原:

E. coli-derived recombinant human protein (amino acids M1-E163) was used as the immunogen for the PIN1 antibody.

克隆性:

Monoclonal (mouse origin)

克隆号:

5E5.

纯化方式:

Antigen affinity purified

保存温度:

After reconstitution, the PIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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