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折扣/货期| 货号：GTX60925 | 规格：50μl | 目录价：￥6600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PKA 2 beta (phospho Ser114) antibody
别名:
protein kinase cAMP-dependent type II regulatory subunit beta , PRKAR2 , RII-BETA
反应种属:
Human, Mouse
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
免疫原:
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PKA regulatory II subunit that contains serine 114. The sequence is conserved in mouse , rat , cow and rabbit.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified from rabbit serum by sequential epitope-specific chromatography.
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
46
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 50% Glycerol, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase | which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adi
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