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折扣/货期| 货号：GTX83827 | 规格：100μl | 目录价：￥7600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PKA I alpha reg antibody [6C7]
别名:
protein kinase cAMP-dependent type I regulatory subunit alpha , ACRDYS1 , ADOHR , CAR , CNC , CNC1 , PKR1 , PPNAD1 , PRKAR1 , TSE1
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-P, WB
同种型:
IgG1
免疫原:
Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector
克隆性:
Monoclonal
克隆号:
6C7
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
43
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
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