Plasma Kallikrein 1B (cleaved Arg390) antibody-多抗-深圳欣博盛生物科技有限公司

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Plasma Kallikrein 1B (cleaved Arg390) antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX86891

规格：100μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Plasma Kallikrein 1B (cleaved Arg390) antibody

别名:

KLK3 , KLKB1 , PKK , PKKD , PPK , kallikrein B1 , Plasma Kallikrein 1B , plasma prekallikrein , plasma kallikrein

反应种属:

Human

宿主来源:

Rabbit

实验应用:

靶标/特异性:

Plasma Kallikrein 1B (cleaved Arg390) antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390.

同种型:

IgG

免疫原:

The antiserum was produced against synthesized peptide derived from human Plasma Kallikrein 1B (341-390).

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]

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