POU1F1 Antibody / PIT-1 / GHF-1-单抗-深圳欣博盛生物科技有限公司

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POU1F1 Antibody / PIT-1 / GHF-1

品牌：NSJ Bio

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说明书

折扣/货期

货号：V4044-100UG	规格：100 ug	目录价：￥6414.1
货号：V4044-20UG	规格：20 ug	目录价：￥2963.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

POU1F1 Antibody / PIT-1 / GHF-1

产品描述:

Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2b, kappa

免疫原:

Recombinant human full-length protein was used as the immunogen for the POU1F1 antibody.

克隆性:

Monoclonal (mouse origin)