Presenilin 1 antibody-多抗-深圳欣博盛生物科技有限公司

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Presenilin 1 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX27297

规格：50μl

目录价：￥4700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Presenilin 1 antibody

别名:

presenilin 1 , ACNINV3 , AD3 , FAD , PS-1 , PS1 , S182

反应种属:

Human

宿主来源:

Goat

实验应用:

ELISA, IHC-Fr, IHC-P, WB

靶标/特异性:

Amino acid sequence 14-33 of human presenilin-1 protein.

同种型:

IgG

免疫原:

Synthetic Peptide: 14AQMSEDNHLSNTVRSQNDNR33

克隆性:

Polyclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

Serum, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

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