Proteosome Activator, 200 kDa antibody-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

Proteosome Activator, 200 kDa antibody

买大送小新年开门红～买大送小，好礼四选一！

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX25620

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Proteosome Activator, 200 kDa antibody

别名:

proteasome activator subunit 4 , PA200

反应种属:

Bovine, Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ICC/IF, IP, WB

同种型:

IgG

免疫原:

Synthetic peptide corresponding to residues T(1620) K L P K K R K R D P G S V G(1634) of human PA200.

克隆性:

Polyclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

211

产品形式:

Liquid

存储溶液:

Serum, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. PA200 has been identified as a 200 kDa nuclear protein that activates the 26S proteasome complex. Studies have shown that, in human tissues, PA200 mRNA levels are highest in testis, but is also present in liver, spleen, brain, heart, kidney and lung. Evidence suggests that this protein is involved in DNA repair, possibly by recruiting the proteasome to double-strand DNA breaks.

您可能感兴趣的产品

Complement C3 antibody

货号：88R-7581

Rabbit Lambda light chain antibody (Prediluted for IHC)

货号：75R-1046

Rabbit Kappa light chain antibody (Prediluted for IHC)

货号：75R-1045

Streptococcus Group A antibody