官网链接
折扣/货期| 货号：GTX83773 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PSMD10 antibody [3F6]
别名:
proteasome 26S subunit, non-ATPase 10 , dJ889N15.2 , p28 , p28(GANK)
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM, WB
同种型:
IgG1
免疫原:
Full length human recombinant protein of human PSMD10 (NP_002805) produced in HEK293T cell.
克隆性:
Monoclonal
克隆号:
3F6
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
24
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and TP53/p53. Overexpression is leading to phosphorylation of RB1 and proteosomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to TP53/p53 and the mono- and polyubiquitination of TP53/p53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
您可能感兴趣的产品
5-methyl-2'-deoxy Cytidine ELISA Monoclonal Antibody
货号：489332
Hyperoxidized Peroxiredoxin-3 Recombinant Monoclonal Antibody (Clone 5H7c)
货号：45463
MARCH6 Monoclonal Antibody (Clone 26F12C)
货号：44928
DHEA-S ELISA Monoclonal Antibody
货号：401169
DNA/RNA Oxidative Damage (Clone 7E6.9) ELISA Monoclonal Antibody
货号：401132
Vitamin D ELISA Monoclonal Antibody
货号：401052
CNP1
货号：355 011AF647
LAMP3
货号：391 308
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询