PTP1B antibody-多抗-深圳欣博盛生物科技有限公司

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PTP1B antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX04098

规格：100μg

目录价：￥6400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PTP1B antibody

别名:

protein tyrosine phosphatase non-receptor type 1 , PTP1B

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

FCM, IHC-Fr, IHC-P, WB

同种型:

IgG

免疫原:

A synthetic peptide corresponding to a sequence at the N-terminus of human PTP1B (4-30aa EKEFEQIDKSGSWAAIYQDIRHEASDF), different from the related mouse sequence by three amino acids, and from the related rat sequence by two amino acids.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05 mg sodium azide.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

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