PVRL4 Antibody / Nectin-4-单抗-深圳欣博盛生物科技有限公司

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PVRL4 Antibody / Nectin-4

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V4056SAF-100UG

规格：100 ug

目录价：￥6414.1

产品详情

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产品名称:

PVRL4 Antibody / Nectin-4

产品描述:

Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2a, kappa

免疫原:

A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody.

克隆性:

Monoclonal (mouse origin)