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折扣/货期| 货号：GTX61991 | 规格：100μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Rad17 (phospho Ser645) antibody [EP1519Y]
别名:
RAD17 checkpoint clamp loader component , CCYC , HRAD17 , R24L , RAD17SP , RAD24
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
The antibody only detects Rad17 phosphorylated on Serine 645.
同种型:
IgG
免疫原:
A phospho-specific peptide corresponding to residues surrounding Serine 645 of human Rad17 was used as immunogen.
克隆性:
Monoclonal
克隆号:
EP1519Y
纯化方式:
Tissue culture supernatant
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
77
产品形式:
Liquid
存储溶液:
50mM Tris-Glycine, 150mM NaCl, 0.05% BSA, 40% Glycerol, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
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