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折扣/货期| 货号：GTX100469 | 规格：100μl | 目录价：￥4000 |
| 货号：GTX100469-S | 规格：25μl | 目录价：￥1700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Rad51 antibody [N1C2]
别名:
RAD51 recombinase , BRCC5 , FANCR , HRAD51 , HsRad51 , HsT16930 , MRMV2 , RAD51A , RECA
产品描述:
RAD51 antibody detects RAD51 protein, also known as RAD51 homolog A. RAD51 (37 kDa) is the indispensable strand exchange factor for homologous recombination in DNA repair. It is also essential for replication fork processing and for genome stability. This RAD51 antibody is a well-cited rabbit polyclonal validated for many applications.
反应种属:
Human, Mouse, Rat, Zebrafish
宿主来源:
Rabbit
实验应用:
IHC-P, IP, WB
靶标/特异性:
KO/KD validation is based on published data (PMID: 23724141).
同种型:
IgG
免疫原:
Recombinant protein encompassing a sequence within the center region of human Rad51. The exact sequence is proprietary.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
0.14 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]
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