官网链接
折扣/货期| 货号：GTX54708 | 规格：100μl | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RAN antibody
别名:
RAN, member RAS oncogene family , ARA24 , Gsp1 , TC4
反应种属:
Human, Monkey, Mouse
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human RAN (NP_006316.1).
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
24
产品形式:
Liquid
存储溶液:
PBS, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
您可能感兴趣的产品
WDR24 antibody
货号：GTX133576
Avian Influenza A virus H9N2 HA (Hemagglutinin) antibody
货号：GTX127306
Influenza A virus M2 (matrix protein) antibody
货号：GTX125951
Acta2 antibody
货号：GTX124505
MCTS1 antibody [N1C3]
货号：GTX117793
MAFG antibody
货号：GTX114541
Golgin 97 antibody [C2C3], C-term
货号：GTX114445
Aconitase 2 antibody [N1N3]
货号：GTX114233
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询