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折扣/货期| 货号：GTX10394 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RANTES antibody [53405.111]
别名:
chemokine (C-C motif) ligand 5 , MuRantes , RANTES , SISd , Scya5 , TCP228
反应种属:
Mouse
宿主来源:
Rat
实验应用:
ICC/IF, Neutralizing/Inhibition
同种型:
IgG2a
免疫原:
purified, E. coli-derived, recombinant mouse RANTES.
克隆性:
Monoclonal
克隆号:
53405.111
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 5% Trehalose, no preservatives.
生产商:
GeneTex
功能与背景:
RANTES is a member of the beta (C-C) chemokine subfamily, which also includes the human proteins MCP1, MCP2, MIP1 alpha, MIP1 beta, I309, and their murine counterparts. Mouse RANTES cDNA encodes a 91 amino acid residue precursor polypeptide with a 23 amino acid residue hydrophobic signal peptide that is cleaved to produce the 68 amino acid residue mature protein (approximately 7.9 kDa). Human and mouse RANTES share approximately 85 % amino acid identity. RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) was first discovered by subtractive hybridization as a transcript expressed in T cells but not B cells. Eosinophillic chemotactic substances released by thrombin stimulated human platelets is identical to RANTES. In addition to T cells and platelets, RANTES is expressed by renal tubular epithelium , synovial fibroblasts, and selected tumor cells (rhabdomyosarcoma cells and MG63 osteosarcoma cells). The mouse RANTES gene maps to chromosome 11. The chemokine RANTES is a chemoattractant for monocytes, T lymphocytes , and NK (natural killer) cells. RANTES selectively attracts T cells of the CD4+/CD45RO+ phenotype in vitro. RANTES can also chemoattract and degranulate eosinophils , as well as chemoattract and induce histamine release from basophils. RANTES has been shown to inhibit HIV-1 entry via human CCR5. RANTES and MIP alpha bind to chemokine receptors (CCR1, CCR4, and CCR5) and induce activation of STAT signaling pathways. Because of its in vitro biological activities, RANTES may play an important role in mediating immune and inflammatory responses.
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