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折扣/货期| 货号：GTX122973-S | 规格：50μg | 目录价：￥1700 |
| 货号：GTX122973 | 规格：50μg | 目录价：￥4000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RBMY1F antibody
别名:
Bcl2 Associated Athanogene 4 , Bag-4 , Sodd , Bag4
实验应用:
Neutralizing/Inhibition
克隆号:
偶联:
Unconjugated
产品浓度:
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store the peptide at -20ºC, stable for one year.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands. Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. Recently, a DR3 associated protein has been isolated by yeast two-hybrid interaction assays. This cDNA encoding a 457-amino acid protein has been named as SODD (Silencer of Death Domain). SODD also associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. SODD overexpression suppressed the TNF induced cell death as well as NF-kB activation. SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state.
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