Recombinant Human Agrin-其他重组蛋白-深圳欣博盛生物科技有限公司

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Recombinant Human Agrin

品牌：PeproTech

官网链接

说明书

折扣/货期

货号：160-08-100UG	规格：100 ug	目录价：￥6741
货号：160-08-10UG	规格：10 ug	目录价：￥1227
货号：160-08-1MG	规格：1 mg	目录价：￥26963
货号：160-08-250UG	规格：250 ug	目录价：￥11746
货号：160-08-500UG	规格：500 ug	目录价：￥17501
货号：160-08-50UG	规格：50 ug	目录价：￥3002

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Recombinant Human Agrin

别名:

AGRN

产品描述:

Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated "y" and "z" display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle. Recombinant Human Agrin is 111.9kDa protein containing 1073 amino acids, corresponding to the 110kDa N-terminal subunit of the full length protein. As a result of glycosylation, Recombinant Human Agrin migrates with an apparent molecular mass of approximately 150-160 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.

宿主来源:

CHO cells

保存温度:

Minus 20C

运输温度:

Room Temperature

产品形式:

Bulk

产地:

美国

生产商:

PeproTech