Recombinant SIGLEC3 Antibody / Sialic acid-binding Ig-like lectin 3 / CD33-单抗-深圳欣博盛生物科技有限公司

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Recombinant SIGLEC3 Antibody / Sialic acid-binding Ig-like lectin 3 / CD33

品牌：NSJ Bio

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说明书

折扣/货期

货号：V5822-100UG	规格：100 ug	目录价：￥6652.1
货号：V5822-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

Recombinant SIGLEC3 Antibody / Sialic acid-binding Ig-like lectin 3 / CD33

产品描述:

Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2b, kappa

免疫原:

A portion of amino acids 100-300 from human CD33 protein was used as the immunogen for the recombinant SIGLEC3 antibody.

克隆性:

Recombinant Mouse Monoclonal