Recombinant SIGLEC3 Antibody / Sialic acid-binding Ig-like lectin 3 / CD33
官网链接
折扣/货期| 货号：V5822SAF-100UG | 规格：100 ug | 目录价：￥6652.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Recombinant SIGLEC3 Antibody / Sialic acid-binding Ig-like lectin 3 / CD33
产品描述:
Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
Mouse IgG2b, kappa
免疫原:
A portion of amino acids 100-300 from human CD33 protein was used as the immunogen for the recombinant SIGLEC3 antibody.
克隆性:
Recombinant Mouse Monoclonal
克隆号:
rSIGLEC3/13503
纯化方式:
Protein G affinity
保存温度:
Aliquot the recombinant SIGLEC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
产品形式:
Purified
存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产地:
美国
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