Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein-单抗-深圳欣博盛生物科技有限公司

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Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein

品牌：NSJ Bio

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说明书

折扣/货期

货号：V5595-100UG	规格：100 ug	目录价：￥6652.1
货号：V5595-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein

产品描述:

TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P

同种型:

Rabbit IgG, kappa

免疫原:

A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.

克隆性:

Recombinant Rabbit Monoclonal