TNFR-Associated Factor 1 Antibody / TRAF1-单抗-深圳欣博盛生物科技有限公司

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TNFR-Associated Factor 1 Antibody / TRAF1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5594SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

TNFR-Associated Factor 1 Antibody / TRAF1

产品描述:

This MAb recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA

同种型:

Mouse IgG1, kappa

免疫原:

A recombinant fragment of human TRAF1 protein (within amino acids 73-219) was used as the immunogen for the TNFR-Associated Factor 1 antibody.

克隆性:

Monoclonal (mouse origin)