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折扣/货期| 货号：GTX17328 | 规格：50μg | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RIP2 antibody [Nick-1]
别名:
receptor interacting serine/threonine kinase 2 , CARD3 , CARDIAK , CCK , GIG30 , RICK , RIP2
反应种属:
Human
宿主来源:
Rat
实验应用:
WB
同种型:
IgG2a
免疫原:
Recombinant fragment, corresponding to N terminal amino acids 1-322 of Human RIP2.
克隆性:
Monoclonal
克隆号:
Nick-1
纯化方式:
Purified IgG2a
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD containing serine/threonine kinase RIP regulates Fas induced apoptosis. A novel CARD containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP like interacting CLARP kinase, receptor interacting protein 2, and CARD containing ICE associated kinase, respectively. RICK contains an N terminal kinase catalytic domain and a C terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF kB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase 1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis and that is involved in the generation of proinflammatory cytokine IL1b. The messenger RNA of RICK is expressed in multiple human tissues.
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