HLA-DR Antibody (MHC II)-单抗-深圳欣博盛生物科技有限公司

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HLA-DR Antibody (MHC II)

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V7421-100UG	规格：100 ug	目录价：￥6652.1
货号：V7421-20UG	规格：20 ug	目录价：￥3082.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HLA-DR Antibody (MHC II)

产品描述:

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain. Polymorphisms yield hundreds of HLA-B and -C alleles.

反应种属:

Human

宿主来源:

Mouse

实验应用:

FACS, WB, IHC-P

同种型:

Mouse IgG1, kappa

免疫原:

Human Bristol 8 cells were used as the immunogen for the HLA-DR antibody.

克隆性:

Monoclonal (mouse origin)