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折扣/货期| 货号：SIH-401-10MG | 规格：10 mg | 目录价：￥1252.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Rolipram
别名:
4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
产品描述:
Autophagy inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
275.35
产品形式:
White to off-white solid.
产地:
加拿大
功能与背景:
Rolipram has been observed to selectively inhibit cAMP-phosphodiesterase (PDE4) by recruiting PDE4 into cytosolic aggregates that are not membrane-encapsulated. A down-stream effect of this observation is the inhibition of autophagy. Under normal conditions, autophagosomes are coated with the autophagic marker light chain 3 (LC3). LC3 binds directly to p62 protein, which shuttles protein to aggresomes, eventually leading to an autophagic event. In the absence of LC3, protein aggregates will not undergo autophagy, and will remain as cytosolic aggregates, as seen with the inhibition of PDE4 by Rolipram. It promotes axonal regeneration (4).
纯度:
>98% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
61413-54-5
分子式:
C16H21NO3
溶解度:
Soluble to 75 mM in DMSO and to 75 mM in ethanol.
PubChem CID:
5092
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