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折扣/货期| 货号：GTX04348 | 规格：100μl | 目录价：￥6200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RPSA antibody [ARC2109]
别名:
ICAS,LAMBR,LAMR1,LBP,LBP/p40,LRP,LRP/LR,NEM/1CHD4,RPSA,SA,lamR,p40,ribosomal protein SA,37LRP,67LR,67kDa Laminin Receptor
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ICC/IF, WB
同种型:
IgG
免疫原:
A synthetic peptide corresponding to a sequence within amino acids 196-295 of human Laminin Receptor (P08865).
克隆性:
Monoclonal
克隆号:
ARC2109
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
33
产品形式:
Liquid
存储溶液:
PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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