Santacruzamate A-抑制剂-深圳欣博盛生物科技有限公司

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Santacruzamate A

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-613-25MG

规格：25 mg

目录价：￥4780.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Santacruzamate A

别名:

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

产品描述:

Ultrapotent HDAC2 inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

278.4

产品形式:

Off-white powder

产地:

加拿大

功能与背景:

Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively) (1). It induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors (2). It has been been investigated as a potential therapeutic agent for breast cancer (3). Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models (4).

纯度:

>98% (TLC); NMR (Conforms)

来源:

Synthetic

CAS号:

1477949-42-0

分子式:

C15H22N2O3

溶解度:

May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml)

PubChem CID:

72946782