SAP97 antibody-多抗-深圳欣博盛生物科技有限公司

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SAP97 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX23437

规格：100μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SAP97 antibody

别名:

discs large MAGUK scaffold protein 1 , B130052P05Rik , Dlgh1 , E-dlg/SAP97 , SAP-97 , SAP97 , mKIAA4187

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ICC/IF, IHC, IHC-Fr, IP, WB

靶标/特异性:

This antibody detects Synapse-Associated Protein 97 (SAP97) from human, rat and mouse tissues. No cross-reactivity to other proteins, including synapse-associated protein family members, has been observed.

同种型:

IgG

免疫原:

Synthetic peptide corresponding to residues V(115) L P S E R I S P Q V P N E V L G P E(133) of rat SAP97.

克隆性:

Polyclonal

克隆号:

纯化方式:

Ammonium sulfate precipitation

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Synapse-Associated Protein 97 (SAP97/human homologue of Drosophila discs-large tumor supressor or HDLG) is one of a family of plasma membrane-associated proteins found in synaptic junctions. This is a novel, presynaptic membrane protein homologous to SAP90 and the Drosophila discs-large tumor supressor protein. SAP97 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP97 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and Shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between SAP97 and other proteins. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP97 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP97 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

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