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折扣/货期| 货号：GTX28120 | 规格：100μg | 目录价：￥7200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SIRP alpha antibody
别名:
BIT , CD172A , MFR , MYD1 , P84 , PTPNS1 , SHPS1 , SIRP , SIRPA , signal regulatory protein alpha , CD172a , SIRP alpha , CD172 alpha
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, ICC/IF, WB
靶标/特异性:
This antibody recognizes human SIRP alpha 1, 2, and 3.
同种型:
IgG
免疫原:
Synthetic peptide corresponding to 17 amino acids within the last 50 amino acids at the C-terminus of human SIRPα. Accession no.: NP_542970 Gene ID: 140885
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
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