SKA2 antibody-多抗-深圳欣博盛生物科技有限公司

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SKA2 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX85247

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SKA2 antibody

别名:

spindle and kinetochore associated complex subunit 2 , FAM33A

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

ELISA, WB

同种型:

IgG

免疫原:

SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2.The immunogen is located within the first 50 amino acids of SKA2.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

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