SLIT2 antibody-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

SLIT2 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX118220	规格：100μl	目录价：￥4000
货号：GTX118220-S	规格：25μl	目录价：￥1700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SLIT2 antibody

别名:

slit guidance ligand 2 , SLIL3 , Slit-2

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

IHC-P, WB

靶标/特异性:

KO/KD validation is based on independent review by YCharOS.

同种型:

IgG

免疫原:

Recombinant protein encompassing a sequence within the center region of human SLIT2. The exact sequence is proprietary.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography.

偶联:

Unconjugated

产品浓度:

0.41 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

170

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.

生产商:

GeneTex

功能与背景:

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

您可能感兴趣的产品

Biotinylated Anti-Human SCGF-beta

货号：500-P99GBT-25UG

Biotinylated Anti-Human Fractalkine (CX3CL1)

货号：500-P98BT-25UG

Biotinylated Anti-Human TARC (CCL17)