官网链接
折扣/货期| 货号：GTX50330 | 规格：100μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Smad1 (phospho Ser465) antibody
别名:
SMAD family member 1 , BSP-1 , BSP1 , JV4-1 , JV41 , MADH1 , MADR1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
This antibody is raised against human Smad1 phosphorylated at Ser465. Based on sequence homology, it is predicted to react with smad5 and smad8(9) when phosphorylated at the corresponding residues - smad5 Ser465 and smad8(9) Ser467.
同种型:
IgG
免疫原:
Peptide sequence around phosphorylation site of serine 465 (I-S-S-V-S(p)) derived from human Smad1.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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