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折扣/货期| 货号：GTX03203 | 规格：100μl | 目录价：￥5900 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SMAD2 (phospho Ser250) antibody [GT1291]
别名:
SMAD family member 2 , JV18 , JV18-1 , MADH2 , MADR2 , hMAD-2 , hSMAD2
反应种属:
Human, Mouse
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
免疫原:
A phospho specific peptide corresponding to residues surrounding S250 of human Smad2.
克隆性:
Monoclonal
克隆号:
GT1291
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
0.56 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
52
产品形式:
Liquid
存储溶液:
PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
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