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折扣/货期| 货号：GTX54855 | 规格：50μl | 目录价：￥10400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
STIM1 antibody
别名:
stromal interaction molecule 1 , D11S4896E , GOK , IMD10 , STRMK , TAM , TAM1
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
FCM, ICC/IF, IHC-P, IP, LCI, WB
同种型:
IgG
免疫原:
Peptide CHSEDEKLSFEAVR, corresponding to amino acid residues 56-69 (STIM1 expressed on the plasma membrane: Extracellular, N-terminus st IM1 expressed on th e ER: Luminal, N-terminus) of human STIM1 (Accession : Q13586).
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
0.45 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
77
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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