STK3 antibody [4G10]-单抗-深圳欣博盛生物科技有限公司

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STK3 antibody [4G10]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX83546

规格：100μl

目录价：￥7300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

STK3 antibody [4G10]

别名:

serine/threonine kinase 3 , KRS1 , MST2

反应种属:

Dog, Human, Monkey, Mouse

宿主来源:

Mouse

实验应用:

IHC-P, WB

同种型:

IgG2b

免疫原:

Full-length protein expressed in 293T cell transfected with human STK3 expression vector

克隆性:

Monoclonal

克隆号:

4G10

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

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