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折扣/货期| 货号：11-129 | 规格：2500U | 目录价：￥7581.6 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Streptococcus pyogenes IdeS Recombinant Protein
别名:
IgG-degrading protease,Sib38,IdeS
实验应用:
WB
表达系统:
E. coli
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
IdeS from Streptococcus pyogenes, also known as Mac-1, is an endopeptidase with specificity for IgG. The bacterial protein Mac-1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity.IdeS is a unique enzyme that digests IgG at a specific site below the hinge region, generating a homogenous pool of F(ab‘)2 and Fc/2 fragments. IdeS digests all subclasses of human, and some classes of monkey, rabbit and sheep IgG. It has limited activity on mouse IgG2a and IgG3 - for digestion of these antibody species. IdeS is cloned from Streptococcus pyogenes and expressed in E. coli.
纯度:
>95% as determined by SDS-PAGE.
Accession #:
WP_010922160.1
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