TCR V beta 5a antibody [1C1]-单抗-深圳欣博盛生物科技有限公司

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TCR V beta 5a antibody [1C1]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79237

规格：200μg

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TCR V beta 5a antibody [1C1]

别名:

T cell receptor beta locus , TCRB , TRB@

反应种属:

Human, Primate

宿主来源:

Mouse

实验应用:

Activation, FCM, ICC/IF, IHC, IHC-Fr

同种型:

IgG1

免疫原:

Human TCR V beta 5(a)

克隆性:

Monoclonal

克隆号:

1C1

纯化方式:

Protein G purified

偶联:

Unconjugated

产品浓度:

0.15 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.5% BSA, Glycerol, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]

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